Study of Metallothionein Levels in the Serum of Patients with Malignant Tumour

Metallothionein (MT) is a low molecular weight intracellular protein, the primary function of which to maintain homeostasis heavy metals in living organisms. Only few research has been carried on topic mechanism MT. Recent points its significant relationship carcinogenesis, spontaneous mutagenesis, and effectiveness antitumor drugs. Increased level MT studied as potential indicator increased metabolic activity cancer. Electrochemical methods are suitable analytical tool for detection. Temperature-denatured blood serum samples patients diagnosed with cancer were using electrochemical analysis (Brdička's reaction). The obtained voltammograms evaluated area under curve (AUC response). To compare normal abnormal levels, control healthy probands (n = 38) an average amount 2.2 µg L–1, median 2.1 L–1 was used. In all 228), 22.7 18.1 L–1. difference (10-fold) between groups highly statistically significant. data from pilot experiment suggest that levels thiol compounds such may have clinical patients.